The Effect of Molecular Imprinting on the Loading and Release of Poorly Water Soluble Drug in Hydrogel Gontact Lenses

Therapeutic contact lenses TCLs is an approach used to enhance corneal residence time and reduce frequent instillation, which a problem with eye drops. The CLs loading of hydrophobic drugs. In this research the were prepared molecular imprinting MI itraconazole, as antifungal drug for fungal keratitis. using different concentration hydroxyethyl methacrylate HEMA methacrylic acid MAA without PEGDA (25 μL) AIBN (37 mg) crosslinker initiator respectively. All clear have good folding endurance. MICLs had significantly higher compared conventional CLs. release itraconazole from was sustained optimum formula chosen 8% due maximum (1077 μg) non-MI (288 more than 24 h. successfully utilized tool poorly water soluble into hydrogel CL.